SLC6A1 and cerebellar ataxia: Chiu et al. (2005) showed that mice lacking the GABA transporter subtype 1 (GAT1) show increased levels of extracellular GABA and reduced motor coordination as assessed in the rotarod as well as tremor and ataxia. In the same line, the GAT1 inhibitor tiagabine, a clinically useful antiepileptic drug, also induces motor incoordination, tremor and ataxia (Salat et al., 2015; Bresnahan et al., 2019).