Hyperammonemia induces neuroinflammation in cerebellum, with activation of microglia and astrocytes, increased levels of TNFα and increased membrane expression of the TNFα receptor TNFR1 (Hernandez-Rabaza et al., 2016; Cabrera-Pastor et al., 2018; Balzano et al., 2020b). This evidence concerns the gene TNFRSF1A and Hyperammonemia.