KLF6-SV1 is one of the KLF6 sub-types, and its expression in the adenocarcinoma group was significantly higher than that in the squamous carcinoma group, correlated with degree of differentiation, lymph node metastasis, and clinical staging [40,65], it was an independent factor affecting 5-year survival in NSCLC patients, promoting Twist1 and CCL2 expression, inducing macrophage polarization and EMT formation for lung cancer metastasis [66]. This evidence concerns the gene KLF6 and lung cancer.