As shown in Fig. 5A–E, compared with the normal group, the levels of IL-1β, iNOS, NO, IL-8 and IL-18 of the diabetes model group were significantly increased (p < 0.05); the levels of IL-1β factors decreased following taurine administration, although there was no statistically significant difference (p > 0.05) between them and the levels of iNOS, NO, IL-8, and IL-18 factors were considerably decreased (p < 0.01). This evidence concerns the gene IL18 and diabetes mellitus.