PTK2 and infection: Because hsa_circ_0002483 is clearly differentially expressed in S. aureus-infected osteoblasts, and its expression level is negatively correlated with PTK2 protein expression levels, hsa_circ_0002483 may negatively regulate epithelial cell signaling upon bacterial invasion by binding to hsa-miR-6886-5p, and subsequently affect the osteoblasts during infection by S. aureus.