Recent studies have demonstrated that TNFRSF1A-mediated signaling contributes to the promotion of tumor formation in various cancers, including liver cancer, skin cancer, gastric carcinogenesis, and esophageal squamous cell carcinoma (ESCC), as well as the facilitation of cancer cell metastasis [56]. Here, TNFRSF1A is linked to esophageal squamous cell carcinoma.