Our study aimed to explore the role of TNFRSF19 in the immunosuppressive environment of glioma due to the connection found between TNFRSF19 expression and the malignant characteristics.The ssGSEA technique was utilized to examine how TNFRSF19 expression levels correlate with the presence of immune cell populations that promote tumor growth, such as MDSCs, neutrophils, and M2 macrophages.High levels of immunosuppressive cells, excluding CD56dim NK cells, are associated with glioma tumors that have elevated TNFRSF19 expression in various groups of patients (P < 0.05, Fig. 7A–C). This evidence concerns the gene TNFRSF19 and central nervous system cancer.