However, the crucial role of JNK–SAB interaction was reported in cardiotoxicity, ischemia/reperfusion cardiac injury, neurotoxicity of the brain, Parkinson’s disease model, and neuronal activity of the brain (Chambers et al., 2011b; Chambers et al., 2013a; Chambers et al., 2013b; Chambers et al., 2017; Sodero et al., 2017). Here, SH3BP5 is linked to Parkinson disease.