In a systematic review, the main psychosocial barriers to insulin initiation were identified as: [1] lack of awareness of the need for insulin treatment, seeking alternative ways for glycemic control without insulin; [2] negative consequences of insulin therapy on lifestyle; [3] perception of insulin treatment as something inaccessible, impractical, and unacceptable; and [4] anxiety associated with insulin treatment (39). This evidence concerns the gene INS and Anxiety.