Since the miR-34a is downregulated in prostate cancer, overexpressing miR-34a downregulates RhoA and suppresses the c-Myc-SKP2 -Miz1 transcriptional assembly complex c-Myc-pTEFB complex that elongates transcription of numerous genes and affects the cellular function (92). The gene discussed is MYC; the disease is prostate carcinoma.