Since the miR-34a is downregulated in prostate cancer, overexpressing miR-34a downregulates RhoA and suppresses the c-Myc-SKP2 -Miz1 transcriptional assembly complex c-Myc-pTEFB complex that elongates transcription of numerous genes and affects the cellular function (92). Here, SKP2 is linked to Familial prostate cancer.