The RNAi-based disruption of anti-miR-196b activity or pharmacologic inhibition of the Cks1-Skp2-containing SCF E3-ubiquitin ligase complexes significantly elevated the level of p27Kip1, which induces monocytic differentiation (60), noticeable reduction of leukemogenic potential, induced apoptosis and suppressing human AML growth (48). This evidence concerns the gene CDKN1B and acute myeloid leukemia.