MiR-216a is involved in the progression of pancreatic cancer through the two-axis, including miR-216a/tetraspanin-1 (TSPAN1)/integrin alpha-2 precursor (ITGA2) and LINC01133/miR-216a-5p/translationally-controlled tumor protein (TPT1). Here, TPT1 is linked to familial pancreatic carcinoma.