LEF1 and familial pancreatic carcinoma: It has been demonstrated that HOTAIR expression in pancreatic cancer cell lines via the Wingless (Wnt)/β-catenin signaling pathway downregulates N-cadherin, β-catenin, vimentin, cyclinD1, c-Jun, Lymphoid enhancer binding factor 1 (LEF1) and cellular myelocytomatosis oncogene (c-myc), upregulate E-cadherin and inhibit epithelial–mesenchymal transition (EMT) (29, 30).