Inhibition of HOTTIP decreases cell proliferation, reduces cell invasion through suppression of EMT and enhances the antitumor effects of gemcitabine in pancreatic cancer in vitro and in vivo (36, 37).HOTTIP has been reported to increase proliferation in pancreatic cancer cells by activating the WNT/beta-catenin signaling pathway. This evidence concerns the gene CTNNB1 and pancreatic neoplasm.