PVT1 can stimulate the Wnt/β-catenin signaling pathways and autophagy through the function of miR-619-5p in the miR-619-5p/autophagy-related 14 (ATG14) and miR-619-5p/pygopus homolog 2 (Pygo2) axes, causing chemo-resistance promotion in pancreatic cancer (50, 55). Here, PVT1 is linked to pancreatic neoplasm.