TLCD1 and esophageal adenocarcinoma: The most common TLCD1 gene alterations were amplifications in bladder urothelial carcinoma, uterine corpus endometrial carcinoma, breast cancer and uterine carcinosarcoma, and mutations in esophageal adenocarcinoma, lung squamous cell carcinoma, gastric carcinoma, lung adenocarcinoma, and cutaneous melanoma (Figure 9A).