STUB1 and cancer: In addition, insights into clonal hematopoiesis of indeterminate potential (CHIP), a known somatic mutation in the cancer community, continue to show links as a possible precursor to CVD, where older adults without cancer with CHIP mutations have a 40 % higher risk of CVD [13], [14], and up to a 25 % higher risk of heart failure compared to non-CHIP controls [15].