TP53 and pancreatic neoplasm: For instance, myeloid cells produce IL-6 to activate the JAK-STAT3pathway that promotes the development of pancreatic ductal adenocarcinoma(PDAC) in a KrasG12D-driven pancreatic tumor mouse model.24,26 Besides, pancreatic-specific Kras and P53 mutations induce an accumulationof reactive oxygen species (ROS) in mouse pancreatic tumors, leadingto activation of STAT3.