STAT3 and cancer: While, in the low level of p-STAT3cell lines, including two cancer cell line PC3 and KG1, and normalcell line HUVEC and HAF, YY002 was relative insensitive to these celllines (Figure 3A,B).Moreover, YY002 inhibited colony formation of multiple STAT3-dependentPDAC cells at concentration of 1 to 10 nM (Supplementary Figure S3A), while YY002 had little impact on STAT3 negativePC3 cells (Supplementary Figure S3B).