STAT3 and familial pancreatic carcinoma: The most promising lead, YY002, a highly potent and selectiveSTAT3 inhibitor, inhibited STAT3 Tyr705 and Ser727 phosphorylation,thereby abrogating the STAT3 nuclear and mitochondrial functions.YY002 potently inhibited pancreatic cancer growth and metastasis in vitro and in vivo.