The most promising lead, YY002, a highly potent and selectiveSTAT3 inhibitor, inhibited STAT3 Tyr705 and Ser727 phosphorylation,thereby abrogating the STAT3 nuclear and mitochondrial functions.YY002 potently inhibited pancreatic cancer growth and metastasis in vitro and in vivo. Here, STAT3 is linked to pancreatic neoplasm.