Owningto the potent antitumor growth effects in vivo, andrecent reports suggesting that STAT3 is involved in key steps of pancreaticcancer metastasis,33,34 we next tested the effects ofYY002 administration on pancreatic tumors in vivo using an orthotopic pancreatic cancer mouse model and a liver metastaticmouse model. The gene discussed is STAT3; the disease is familial pancreatic carcinoma.