We examined polySTING’s mechanismin the same model and found a strong DC-driven antitumor immune response.Specifically, polySTING strongly enhanced CD8+ cDC1 responsesalong with TME T-lymphocyte infiltration and CD8+ T cellactivation while promoting DC maturation in the tumor-draining lymphnodes (TDLN). The gene discussed is CD8A; the disease is neoplasm.