STING1 and neoplasm: In tumor rejection models with or without immunotherapy,DC subsets such as type-1 conventional DCs (cDC1) play indispensableroles in antigen transport, cross-priming, and lymphocyte recruitmentand maintenance in the TME.28−32 STING activation in DCs strongly induces DC maturation,33 and activation in cDC1 was crucial to the functionof an intratumoral viral vector STING delivery platform.27 We hypothesize that a STING delivery platformtargeting tumoral APCs can induce potent antitumor responses withminimal toxicity.