REL and cancer: Interaction of RIP 1 and 3 with the matured NF-KB p52 is known to form a heterodimer with the Rel NF-KB. Subsequent translocation of the ensuing active NF-KB complex into the nucleus and DNA binding stimulates the transcription of cytokines to potentiate MLKL membrane permeabilization or pore formation.61 The significant DAMP release and slow cancer cell death in the absence of immune cells in vitro supports RaST-mediated immunogenic cell death mechanism and highlights the potential of using RaST in combination therapies.