Currently, two theories for the involvement of WMH in AD exist: (1) additive theory, where WMH is primarily due to cerebrovascular disease and it lowers the threshold for AD diagnosis independent of AD pathology, and (2) interactive theory, where WMHs interact with amyloid/tau to potentiate their effects on cognitive impairment [19]. The gene discussed is MAPT; the disease is Cognitive impairment.