RUNX3 and acute myeloid leukemia: We performed quantitative analysis of nuclear morphology, which revealed significantly low sphericity of SRSF2 Mut cells compared to that of untreated WT MOLM14 and OCI-AML2 cells, and the severity of this phenotype was extensively augmented by RKI-1447 treatment in MOLM14, OCI-AML2, and primary AML samples (Figure 4B).