SRSF2 and chronic myelomonocytic leukemia: SRSF2 mutations are the most common splicing machinery mutations (SMMs) identified in various myeloid malignancies (acute myeloid leukemia [AML], myelodysplastic syndrome [MDS], chronic myelomonocytic leukemia [CMML], and myeloproliferative neoplasms [MPNs]).