ITIH4 and HIV infectious disease: Chen et al. recently developed, by virtue of FDM printing, a novel reservoir IVR that can provide the tunable, controlled release of hydroxychloroquine (HCQ), immunoglobulin G (IgG) and enveloped glycoprotein GP120 (GP120) fragment, and coumarin 6-encapsulated PLGA-PEG nanoparticles, to potentially offer a comprehensive and potentially synergistic protection against HIV infection in the female vaginal tract [41].