Still regarding microglia cells, anthocyanins were also able to mitigate oxidative stress and neurodegeneration in a mouse model of AD by modulating the PI3K/Akt/Nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) axis (294). This evidence concerns the gene NFE2L2 and Alzheimer disease.