Though a direct anti-leukemic function of IFN may not be required for effective GVL, IFNɣ has been shown to upregulate expression of MHC class II genes in AML and blast crisis CML cells, whereas chronic phase CML cells were sensitive to GVL effects independent of IFNɣ (175). The gene discussed is IFNA1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.