Twenty-two were relevant to ICI-IA, including diagnosis codes for unspecified joint pain, knee pain, and unspecified osteoarthritis (osteoarthritis was likely a placeholder early in the diagnostic workflow); laboratory test and procedure codes for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, and anti-CCP antibody tests; medication codes for prednisone and methylprednisolone. This evidence concerns the gene CRP and osteoarthritis.