It was also reported that increased GD2 expression in cancer cells is associated with NF-κB, and treatment with IKK (inhibition of NF-κB signaling) inhibitors in an experimental model reducing breast cancer metastasis to the lung by more than 5-fold (34), which also suggests the influence of GD2 on metastasis and cell migration. The gene discussed is NFKB1; the disease is breast carcinoma.