Conversely, two traits showed protective connections with psoriasis: CD28 on CD39+ activated Treg (IVW: OR 0.9995, 95% CI 0.9990–1.0000; p = 3.250596e−02), CD25 on CD39+ CD4 Treg (IVW: OR 0.9984, 95% CI 0.9973–0.9995; p = 3.969029e−03). This evidence concerns the gene ENTPD1 and psoriasis.