Protein profiling of tumor lysates for the untreated, CPA-, GLV-1h68- and combination treatments showed that host-derived pro-inflammatory cytokines and chemokines, such as eotaxin, MIP-1β, MCP-1, MCP-3, MCP-5, TNF-α, and MPO, are upregulated in tumor tissues after viral infection and combination therapy OVVs may synergizes with irinotecan (CPT-11) in human colorectal adenocarcinoma. The gene discussed is TNF; the disease is neoplasm.