INS and liver dysplastic nodule: Twelve weeks of intervention with 25 g of probiotic honey containing 108 CFU/g of Bacillus coagulans T11 (IBRC-M10791) in 30 DN patients in a double-blind RCT revealed extensively lower serum insulin levels (−1.2 ± 1.8 vs. −0.1 ± 1.3 μIU/mL, p=0.004), HOMA-IR levels (−0.5 ± 0.6 vs. 0.003 ± 0.4, p=0.002), and drastically increased quantitative insulin sensitivity check index (+0.005 ± 0.009 vs. −0.0007 ± 0.005, p=0.004) compared to the other 30 DN patients who received 25 g of non-probiotic honey per day [30].