VEGFA and hematologic disorder: The results of this study align with the known anti-inflammatory properties of Lenalidomide and Pomalidomide, which have been extensively utilized in the treatment of hematological malignancies [7]. Prostaglandins produced by Pg-protein can promote inflammation within the tumor microenvironment, contributing to cancer development, progression, and metastasis, Pg-protein amino acids can also modulate angiogenic processes by promoting the expression of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin [8].