PCOS-induced group LH and estrogen concentration increased while progesterone and FSH concentration decreased (p<0.05) compared to the control group. In clomiphene and ginger extract groups, there was an improvement in hormonal secretion (p<0.05). Clomiphene had a better effect on improving sexual hormones in PCOS than lower-dose ginger. Ginger extract at higher doses has better effects in improving PCOS. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.