TNF and endometriosis: MMP-9 activity increased gradually in endometriotic tissues with severity and curcumin treatment reversed the MMP-9 activity near to control value (p<0.001). Curcumin administered either post- or pre-endometriosis arrested endometriosis in a dose-dependent manner (p<0.001). MMP-9 activity (p<0.001) and expression, as well as TNF-α expression, decreased with curcumin exposure. Curcumin prevented lipid peroxidation and protein oxidation in endometrial tissues (p<0.001)