Letrozole-induced PCOS caused an increase in LH (P=0.001), glucose, cholesterol, and triglycerides, and a decrease in estrogen, progesterone, FSH, and adiponectin (p=0.0001). Turmeric extract reversed the levels of LH, glucose, cholesterol, triglycerides, estrogen, progesterone, FSH (p=0.0001), and adiponectin (p=0.01). This evidence concerns the gene ADIPOQ and polycystic ovary syndrome.