However, the study had a very low sample size and may not be generalizable. In a randomized controlled trial on women with PCOS by Shorevardi et al. [30], the effects of metformin alone versus metformin in combination with curcumin nanomicelle on blood triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, plasma glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), insulin resistance (HOMA-IR), and insulin-sensitivity check index (QUICKI) were assessed. The gene discussed is INS; the disease is polycystic ovary syndrome.