It was highly encouraging that our novel AAV variants, Pep2hSC1 and Pep2hSC2, demonstrated the strongest performance in hSCs isolated from a plexiform neurofibroma among the AAVs tested, despite the fact the percentage of transduced S100+ cells was lower than what was observed at the same dose in hSC isolated from healthy donors (Figures 2 and 3). Here, S100B is linked to plexiform neurofibroma.