PERK phosphorylation (Fig. 14B–D), the expression of PDI (Fig. 14B, C, H), the expression of ERO1-Lα (Fig. 14B, C, I), and the expression of the proapoptotic protein Chop (Fig. 14B, C, J) were higher in the DS brains than in the wild-type control brains. This evidence concerns the gene P4HB and Dravet syndrome.