Some of the markedly upregulated proteins in DS include lactoylglutathione lyase (LGUL) and methylmalonyl-CoA mutase (MUTA)—both of which are also encoded by mouse chromosome 17, although not by the segment that contains an extra copy in the current model—LIM and calponin homology domain–containing protein 1 (LIMC1) and membrane-associated phosphatidylinositol transfer protein 2 (PITM2), both of which are encoded on mouse chromosome 5 (Fig. 17, Table S2). The gene discussed is PITPNM2; the disease is Dravet syndrome.