Proteins with markedly decreased persulfidation in male DS mice include unconventional myosin-XVIIIa, Ras-related protein Rap-2a, ubiquitin conjugation factor E4 B, the RNA-binding protein vigilin, adenylate kinase isoenzyme 5, and aldehyde dehydrogenase family 3 member B1. The gene discussed is AK5; the disease is Dravet syndrome.