We could not analyze comparatively the condition of sick WT (WT CIA) mice and WT non-CIA mice on day 48, because, as indicated, all immunized WT mice had developed arthritis at that time stage, Therefore, we compared the phenotypic profile of WT CIA mice with that of control, non-immunized WT ones and then, with that of the arthritis suffering EphB3-mutant mice. The gene discussed is EPHB3; the disease is arthritic joint disease.