We established the following experimental groups: WT mice with arthritis (WT CIA) or without it (WT non-CIA), EphB2 mutant mice that did not suffer the disease (EphB2−/− non-CIA) and EphB3−/− mice that developed the disease (EphB3−/− CIA) or not (EphB3−/− non-CIA), and the following comparative analyses were carried out:. This evidence concerns the gene EPHB3 and arthritic joint disease.