The Mexican American sample also has greater proportions of current smokers and diagnoses of T2D, hypertension, anemia, mild cognitive impairment, and dementia, a smaller proportion of those with APOE4 positivity, lower MMSE and self-rated health, as well as greater GDS, BMI, and Ab circumference, blood glucose and HbA1c, Ab42/40 ratio, t-tau, and NfL. The gene discussed is APOE; the disease is hypertensive disorder.