MAPT and Alzheimer disease: Interestingly, of the cross-region AD-associated clusters 2, 4, 5, and 8, clusters 2 and 4 showed the highest density of microglia nuclei in the early and late tau bins, while clusters 5 and 8 showed a high density of microglia nuclei in the late Aβ bin (Fig. 3c, Table S9, Table S10), suggesting differential early vs. late responses of these microglial clusters to tau and Aβ pathologies.