IL4 and Alzheimer disease: Phasic genes from homeostatic (cluster 0) to AD-associated clusters 3, 4, and 5 included genes implicated in CDC24 GTPase cycle, RHO GTPase cycle, fibrin clot formation, IRAK1 recruitment of IKK complex (Fig. 4b, top, cluster 0 to 3), IL-4/IL-13 signaling, response of EIF2AK1 to heme deficiency, signaling by interleukins, IFNγ signaling (Fig. 4b, middle, cluster 0–4), and genes involved in axon guidance, fibrin clot formation, semaphorin interactions, and IL-4/IL-13 signaling (Fig. 4b, bottom, cluster 0 to 5).