Prior mouse scRNA-seq studies have identified a Trem2-dependent and a subsequent Trem2-independent stages of AD progression in the 5xFAD model, termed DAM1 and DAM2, respectively [27], as well as two additional DAM phenotypes, early DAM (EADAM), increased in dual Aβ and tau pathology mice, compared to single pathology mice, and late DAM (LADAM) [28]. This evidence concerns the gene MAPT and Alzheimer disease.