In contrast, Cd4−/− mice showed increased susceptibility to a broad range of experimentally induced pathogen infections, including Staphylococcus aureus (Mohammed et al., 2000), lymphocytic choriomeningitis virus (Battegay et al., 1994; Fuller et al., 2004; Khanolkar et al., 2004; Pien et al., 2002; Sun and Bevan, 2004), Cryptococcus neoformans (Kawakami et al., 2001), Mycobacterium tuberculosis (Serbina et al., 2001), rotavirus (VanCott et al., 2001), prions (Lewicki et al., 2003), Ehrlichia (Bitsaktsis et al., 2004), or hepatitis virus (Chakravarty et al., 2020). This evidence concerns the gene CD4 and infection.