CEBPA and Hepatic fibrosis: Consistently, Cebpa mRNA was time-dependently decreased in the livers and hepatocytes of mice fed a high-fat, high-cholesterol, high-fructose diet (HFCFD) for 13 or 26 weeks during the development of liver fibrosis, accompanied by decreased liver CEBPA protein, especially the 42 kD isoform (Figure 1, J–L and Supplemental Figure 1E).