Herein, by using a hepatocyte-specific constitutive or inducible CEBPA-deficient mouse strain in combination with adeno-associated virus serotype 8–forced (AAV8-forced) CEBPA overexpression, the pathological function of hepatocyte-specific CEBPA in regulating liver fibrosis was examined and the mechanism was identified. The gene discussed is CEBPA; the disease is Hepatic fibrosis.