SPP1 and Hepatic fibrosis: AAV8-TBG-Cebpa increased hepatic Cebpa mRNA and CEBPA protein, while decreased hepatic Spp1 mRNA, serum OPN, hepatic lipid accumulation, and liver fibrosis, accompanied by a reduction in liver TG, serum ALT, and NEFA without changing other parameters (Figure 8, F–J and Supplemental Figure 10, E–H).