MAPK3 and Hepatic fibrosis: However, both sets of CebpaΔHep,ERT2 mice consistently developed markedly enhanced liver fibrosis as revealed by increased hepatic inflammation- and fibrosis-related mRNAs (Figure 3, B and D), while the stiffness of livers was much higher in HFCFD-fed CebpaΔHep,ERT2 mice, indicating increased liver cirrhosis (Figure 3E).