KAT6B and memory impairment: While vehicle-treated Kat6b+/+ control mice learned to reduce the proportion of random searches and increased the proportion of spatial access to the target hole over the training and recall sessions, neither vehicle- nor VPA-treated Kat6b+/– mice showed an increase in spatial access and even VPA-treated Kat6b+/+ mice failed to display learning in this test (Figure 8J), indicating that VPA not only failed to improve the spatial learning and memory impairment in Kat6b+/– mice, but also compromised the spatial learning and memory of WT mice.