As KAT6B has been implicated in mitochondrial function in Alzheimer’s disease (14) and aspects of the KAT6B-related KAT6A syndrome have been proposed to arise from mitochondrial dysfunction (15), we assessed mitochondrial morphology and function across SBBYSS HEK293T cell lines. This evidence concerns the gene KAT6B and autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome.