By detecting the system xc(−) cystine/glutamate antiporter (xCT) level, total Fe concentration and LPO, we confirmed that ferroptosis levels were significantly increased in bone marrow neutrophils of TBI-induced depression mice, which was significantly alleviated by conditional knockout of FOXO1 in neutrophils (Fig. 6c-e). Here, FOXO1 is linked to major depressive disorder.