This notion is further emphasized by work from Ardeljan et al. wherein they found that LINE-1 overexpression is incompatible with cellular growth of non-transformed cells harboring wildtype p53 partly due to retrotransposition-mediated replication stress, suggesting LINE-1 upregulation may represent an early selection pressure by which some cancers acquire p53 mutations [132, 133]. Here, TP53 is linked to cancer.