Given the critical role of microglial scavenging and cleaning function in synaptic pruning, coupled with Cyfip1’s implication in synaptic homeostasis [13] and its enrichment in cortical inhibitory synaptic sites [44], we posited that PWS T1 might suffer from impaired synaptic stabilization and function. The gene discussed is CYFIP1; the disease is Prader-Willi syndrome.