This PWS T1-associated microglial dysmorphism was not found in controls and PWS T2 subjects, in which the Iba1-ir microglia throughout the hypothalamus were morphologically intact, with few visible primary processes (Control: 1.48 ± 0.31/cell, PWS T2: 1.70 ± 0.26/cell, p = 0.62). The gene discussed is AIF1; the disease is Prader-Willi syndrome.