ORM2 and rheumatoid arthritis: Moreover, serum ORM2 concentrations at baseline were significantly higher in the subgroup of RA patients (n = 14) with radiographic progression than in those without such progression (n = 76), which was determined using the serial X-ray images from patients collected over 2 years (median serum ORM2 levels [IQR]: 10,310 [4,710-12,870] ng/mL for the progression group and 1,090 [340-1,545] ng/mL for the nonprogression group; P < 0.001) (Fig. 7e).