ORM2 and rheumatoid arthritis: In support of this, recombinant human ORM2 (1 μg/mL) time-dependently increased NF-κB translocation from the cytoplasm to the nucleus in RA-FLSs and upregulated the phosphorylation of NF-κB p65 (Fig. 3b, c), while it downregulated IκB expression up to 2 h after stimulation (Fig. 3c).