We found that several genes [C-C chemokine receptor type 2 (Ccr2), Ccr5, and C-X-C Motif Chemokine Ligand 12 (Cxcl12)] involved in immunosuppression during cancer progression were downregulated upon Mbd2 deletion (indicated by the arrows in the heatmap in Fig. 7a). This evidence concerns the gene CXCL12 and cancer.