The expression of the corresponding orthologous genes in human breast cancer patients represented in the TCGA database showed that XIST expression was significantly downregulated, consistent with previous observations showing repression of Xist by MBD252, while the expression of CCT6A and PVT1 was significantly upregulated in patient breast tumors (Supplementary Fig. 3c). The gene discussed is XIST; the disease is breast carcinoma.