In this study, we constructed a prognostic signature consisting of 9 circadian rhythm-related genes (ADA, ICOS, ALG3, STC1, CYP4X1, EZH2, OLR1, PLEKHA6, and STARD4) to predict the prognosis of HNSCC patients. Here, STC1 is linked to head and neck squamous cell carcinoma.