We observed that most of the genes (i.e., IFNB1, IFNL1, IFNL2/3, IFIT1, IFIT3, OAS1, and CXCL10) were expressed significantly higher in NHBE cells coinfected with both viruses when OC43 virus infection followed IAV 24 h postinfection compared with IAV (2‐fold) or OC43 virus (219‐fold) infection alone (Figures 2A and S2). The gene discussed is IFNB1; the disease is viral infectious disease.