A series of subsequent studies have found that H2 also maintains redox balance in the body by activating the Keap1-Nrf2-ARE, and Nrf2-HO-1 pathways (Slezak et al. 2021; Xie et al. 2020; Yu et al. 2019; Chen et al. 2015), which exerts immunomodulatory, anti-inflammatory, and cancer pro-apoptotic effects. This evidence concerns the gene HMOX1 and cancer.