The mean DM duration was 5.3 ± 5.1 years, and as the duration increased, there was a consistent linear rise in the prescription of more than three oral antihyperglycemic agents (0.0% in the new-onset group, 18.4% in the < 5 years group, 35.3% in the 5–9 years group, and 51.8% in the ≥ 10 years group) and insulin (0.0% in the new onset group, 6.8% in the < 5 years group, 8.3% in the 5–9 years group, and 20.6% in the ≥ 10 years group). The gene discussed is INS; the disease is diabetes mellitus.