For example, four members of NADH dehydrogenase (Ndufa2, Ndufa7, Ndufs5, and Ndufv3) were all uniquely present in the BMEF (Table S3), indicating specific extracellular function for these metabolic enzymes in BMEF and possible unique regulation of the leukemia microenvironment of adults, as suggested for other cancers [52]. This evidence concerns the gene NDUFV3 and leukemia.