Innate Fe-Redox regulators such as lactoferrin (LF), heme oxygenase (HO)-1, erythropoietin (EPO), and hepcidin (HEP) serve as front-line innate barriers against free radical (ROS/RNS) damage and hyper-immune responses during COVID-19 and PASC27. This evidence concerns the gene HMOX1 and COVID-19.