A secondary classification related to the handedness of relative orientations of specific repeats in tauopathies, recovers the isoform composition of tau inclusions (3R + 4R tauopathy and 3R tauopathy) and four-layered (CBD and AGD) and three-layered (PSP, GGT and GPT) folds but, in addition, it also distinguishes GPT from PSP. This evidence concerns the gene MAPT and argyrophilic grain disease.