In addition, the research aimed to analyze the expression of transcript variants of PTGS1 (COX-1) and PTGS2 (COX-2) genes in the pathobiology of CRSwNP indicates that the COX1.3, COX1.4, COX1.5, and COX2.1 variants may promote milder CRSwNP course. This evidence concerns the gene PTGS2 and chronic rhinosinusitis with nasal polyps.