COX11 and chronic rhinosinusitis with nasal polyps: On the contrary, the variants COX1.1, COX1.2, and COX2.2 may be involved in a more aggressive CRSwNP disease38. Therefore, our current results not only provide information concerning COX-2 expression and distribution in NP tissues but may also suggest the existence of geographic variability among human species with CRSwNP.