In addition, the research aimed to analyze the expression of transcript variants of PTGS1 (COX-1) and PTGS2 (COX-2) genes in the pathobiology of CRSwNP indicates that the COX1.3, COX1.4, COX1.5, and COX2.1 variants may promote milder CRSwNP course. Here, COX15 is linked to chronic rhinosinusitis with nasal polyps.