To confirm our PCR array result which COX-2 gene is significantly upregulated for 2.31 folds in NP tissues of Taiwanese patients with CRSwNP than nasal mucosa tissues of controls12, the 24 control, CRSsNP, and CRSwNP patients were recruited in this study. This evidence concerns the gene PTGS2 and chronic rhinosinusitis without nasal polyps.