On the contrary, the variants COX1.1, COX1.2, and COX2.2 may be involved in a more aggressive CRSwNP disease38. Therefore, our current results not only provide information concerning COX-2 expression and distribution in NP tissues but may also suggest the existence of geographic variability among human species with CRSwNP. This evidence concerns the gene PTGS2 and chronic rhinosinusitis with nasal polyps.