We investigated whether CAP1 was required to induce PCSK9-mediated atherosclerosis using a model of partial ligation of the carotid artery to induce D-flow at the distal end15 under high-fat diet conditions in WT and Cap1+/− mice with or without tail vein injection of AdV-PCSK98 (Fig. 8a). The gene discussed is PCSK9; the disease is atherosclerosis.