Furthermore, a previous study indicated that high levels of p-GSK3β are more sensitive to PQR309, and the combination of PQR309 with a GSK3β inhibitor or GSK3β gene silencing had a synergistic anti-tumor effect in glioblastoma [85], suggesting that there may be a regulatory relationship between PQR309 and GSK3β, which could also support our results. Here, GSK3B is linked to neoplasm.