PTPRC and neoplasm: It showed that in the PGRN−/− group fewer tumor-associated macrophages (TAMs; CD45+F4/80+) were identified; conversely, T cells (CD45+CD3+) were significant increased, but there were no significant differences in B cells (CD45+B202+), NK cells (CD45+NK1.1+) and neutrophils (CD45+Gr1+) (Fig. 2A, B).