As shown in Fig. 1C, though the tumor volume of PGRN−/− mice by orthotopic xenograft was smaller compared with the PGRN WT mice, PGRN knock-off in mice did not prevent tumorigenesis of PGRN WT PY8119 cell, which hinted that PY8119-derived PGRN played a dominate role in tumor growth compared to mice-derived PGRN (Fig. 1C). This evidence concerns the gene GRN and neoplasm.