Moreover, anti-PD-1 treatment did not significantly alter CD69 expression levels in CD8+T cells isolated from PY8119 Grn WT tumors, whereas depletion of tumor-derived PGRN led to a significant up-regulation of CD69 expression in CD8+T cells in response to anti-PD-1 administration (Fig. 7E). The gene discussed is GRN; the disease is neoplasm.