Interestingly, when spleen T cells were co-cultured with murine tumor-derived macrophages in the presence or absence of ICAM-1 neutralizing antibody, we found that there was no significant effect on the positive ratio of Ki67 in CD8+T cells, which indicated that ICAM-1 did not alter the proliferation of CD8+T cells (Fig. 4D). Here, CD8A is linked to neoplasm.